\uff082024\u5e746\u670824\u65e5\uff0c\u5317\u4eac\uff09\u5f3a\u751f\u4eca\u65e5\u5ba3\u5e03\uff0c\u65d7\u4e0b\u6bcf\u516d\u4e2a\u6708\u7ed9\u836f\u4e00\u6b21\u7684\u957f\u6548\u9488\u5242\u5584\u4e45\u8fbe\u00ae\uff08\u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\u6ce8\u5c04\u6db2(6M)\uff0cINVEGA HAFYERA\u00ae\uff0c\u82f1\u6587\u901a\u7528\u540d\u79f0\uff1aPaliperidone Palmitate Injection (6M)\uff09\u8fd1\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u8bb8\u53ef\u6279\u51c6\uff0c\u7528\u4e8e\u63a5\u53d7\u8fc7\u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\u6ce8\u5c04\u6db2(3M)\u81f3\u5c113\u4e2a\u6708\u5145\u5206\u6cbb\u7597\u7684\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005[1]\u3002<\/p>\n
\u4f5c\u4e3a\u5f3a\u751f\u957f\u6548\u9488\u5242\u5bb6\u65cf\u7684\u65b0\u6210\u5458\uff0c\u5584\u4e45\u8fbe\u00ae\u662f\u76ee\u524d\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e14\u552f\u4e00\u4e00\u6b3e\u4e00\u5e74\u4ec5\u9700\u6ce8\u5c04\u4e24\u6b21\u7684\u957f\u6548\u9488\u5242\u6297\u7cbe\u795e\u75c5\u836f[2]\uff0c\u901a\u8fc7\u5728\u6ce8\u5c04\u90e8\u4f4d\u7f13\u6162\u91ca\u653e\u8fdb\u5165\u8840\u6db2\uff0c\u5b9e\u73b0\u957f\u8fbe\u516d\u4e2a\u6708\u7684\u6301\u7eed\u6cbb\u7597\u548c\u75c7\u72b6\u63a7\u5236[3]\u3002\u5728\u5df2\u6709\u4ea7\u54c1\uff08\u4e00\u6708\u4e00\u9488\u7684\u5584\u601d\u8fbe\u00ae\u548c\u4e09\u6708\u4e00\u9488\u7684\u5584\u59a5\u8fbe\u00ae\uff09\u7684\u57fa\u7840\u4e0a\uff0c\u5f3a\u751f\u57fa\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5b9e\u9645\u7528\u836f\u9700\u6c42\uff0c\u6301\u7eed\u4f18\u5316\u4ea7\u54c1\uff0c\u4e3a\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u5168\u75c5\u7a0b\u6cbb\u7597\u548c\u7ba1\u7406\uff0c\u63d0\u4f9b\u6301\u4e45\u7a33\u5b9a\u53ef\u5347\u7ea7\u7684\u8bca\u7597\u65b9\u6848\u3002<\/p>\n
\u7cbe\u795e\u5206\u88c2\u75c7\u662f\u4e00\u7ec4\u7531\u9057\u4f20\u3001\u751f\u7269\u53ca\u73af\u5883\u7b49\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u7684\u4e25\u91cd\u7cbe\u795e\u75be\u75c5\uff0c\u5e38\u6709\u77e5\u89c9\u3001\u601d\u7ef4\u3001\u60c5\u611f\u548c\u884c\u4e3a\u7b49\u65b9\u9762\u7684\u969c\u788d[4]\u3002\u7531\u4e8e\u75c5\u7a0b\u957f\u3001\u75c5\u60c5\u91cd\u3001\u6613\u53cd\u590d\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7ed9\u60a3\u8005\u3001\u5bb6\u5c5e\u53ca\u793e\u4f1a\u5e26\u6765\u4e86\u4e25\u91cd\u75be\u75c5\u8d1f\u62c53\u3002\u76f8\u5173\u7814\u7a76\u663e\u793a\uff0c\u4e2d\u56fd\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u51fa\u9662\u540e\u4e00\u5e74\u5185\u7684\u590d\u53d1\u7387\u9ad8\u8fbe33.4%[5]\uff0c\u800c\u4e2d\u65ad\u670d\u836f\u6216\u81ea\u884c\u51cf\u836f\u662f\u75be\u75c5\u590d\u53d1\u7684\u91cd\u8981\u539f\u56e05\u3002<\/p>\n
\u4e0e\u53e3\u670d\u836f\u7269\u76f8\u6bd4\uff0c\u957f\u6548\u9488\u5242\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u4e2d\u5177\u6709\u8bb8\u591a\u4f18\u52bf\uff0c\u5305\u62ec\u63d0\u9ad8\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u3001\u907f\u514d\u53cd\u590d\u63d0\u9192\u60a3\u8005\u7528\u836f\u3001\u66f4\u4fbf\u6377\u3001\u964d\u4f4e\u610f\u5916\u6216\u8fc7\u91cf\u670d\u836f\u98ce\u9669\u7b49[6]\u3002\u7ed9\u836f\u95f4\u9694\u66f4\u957f\u7684\u957f\u6548\u9488\u5242\u80fd\u66f4\u597d\u5730\u652f\u6301\u75be\u75c5\u7ba1\u7406\uff0c\u52a9\u529b\u60a3\u8005\u5b9e\u73b0\u56de\u5f52\u5bb6\u5ead\u548c\u793e\u4f1a\u7684\u7ec8\u6781\u76ee\u6807[7],[8]\u3002<\/p>\n
\u201c\u6b64\u6b21\u5584\u4e45\u8fbe\u00ae\u7684\u83b7\u6279\uff0c\u518d\u6b21\u5f70\u663e\u4e86\u5f3a\u751f\u4e09\u5341\u4e5d\u5e74\u6765\u5bf9\u4e2d\u56fd\u60a3\u8005\u7684\u6301\u7eed\u5173\u7231\u3002\u4f5c\u4e3a\u6df1\u8015\u7cbe\u795e\u536b\u751f\u9886\u57df\u7684\u521b\u65b0\u9886\u5bfc\u8005\uff0c\u6211\u4eec\u6df1\u77e5\u957f\u6548\u9488\u5242\u7b49\u521b\u65b0\u836f\u7269\u5bf9\u60a3\u8005\u7684\u91cd\u8981\u6027\uff0c\u5e76\u5c06\u6301\u7eed\u4f18\u5316\u6211\u4eec\u7684\u4ea7\u54c1\u7ebf\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u7684\u9009\u62e9\u3002\u201d\u5f3a\u751f\u521b\u65b0\u5236\u836f\u4e2d\u56fd\u533a\u603b\u88c1Cherry Huang\u8868\u793a\uff0c\u201c\u672a\u6765\uff0c\u6211\u4eec\u5c06\u4e0e\u653f\u5e9c\u548c\u76f8\u5173\u673a\u6784\u7d27\u5bc6\u5408\u4f5c\uff0c\u5c3d\u5feb\u5f15\u8fdb\u5584\u4e45\u8fbe\u00ae\u8fd9\u4e00\u9769\u65b0\u6027\u6cbb\u7597\u65b9\u6848\uff0c\u786e\u4fdd\u6211\u4eec\u7684\u7a81\u7834\u6027\u6210\u679c\u80fd\u591f\u52a9\u529b\u66f4\u591a\u60a3\u8005\u56de\u5f52\u6b63\u5e38\u751f\u6d3b\u3002\u201d<\/p>\n
\u652f\u6301\u6b64\u6b21\u5584\u4e45\u8fbe\u00ae\u4e0a\u5e02\u8bb8\u53ef\u6279\u51c6\u7684\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u975e\u52a3\u6548\u7684\u5168\u7403\u4e34\u5e8a3\u671f\u7814\u7a762\u6570\u636e\u8868\u660e\uff0c\u572812\u4e2a\u6708\u671f\u672b\uff0c\u5584\u4e45\u8fbe\u00ae\u5728\u9884\u9632\u75be\u75c5\u590d\u53d1\u65b9\u9762\u4e0e\u5584\u59a5\u8fbe\u00ae\u76f8\u6bd4\u5177\u6709\u975e\u52a3\u6548\u6027\uff08\u5373\u4e0e\u5584\u59a5\u8fbe\u00ae\u5177\u6709\u76f8\u5f53\u7684\u6cbb\u7597\u6548\u679c\uff09\u3002\u540c\u65f6\uff0c\u5728\u8be5\u7814\u7a76\u57fa\u7840\u4e0a\u5f00\u5c55\u7684\u5f00\u653e\u6807\u7b7e\u6269\u5c55\u7814\u7a76[9]\u7ed3\u679c\u63d0\u793a\uff0c96.1%\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u63a5\u53d7\u5584\u4e45\u8fbe\u00ae\u6cbb\u75972\u5e74\u6ca1\u6709\u590d\u53d1\u3002<\/p>\n
###<\/p>\n
\u5173\u4e8e<\/strong>\u5584\u4e45\u8fbe<\/strong>\u00ae<\/strong>\uff08\u68d5\u6988\u5e15\u5229<\/strong>\u54cc\u916e\u916f<\/strong>\u6ce8\u5c04\u6db2<\/strong>(<\/strong>6M<\/strong>)<\/strong>\uff09<\/strong>1<\/strong><\/p>\n \u5584\u4e45\u8fbe\u00ae\u4e3a\u6bcf 6 \u4e2a\u6708\u7ed9\u836f\u4e00\u6b21\u7684\u6ce8\u5c04\u6db2\uff08\u6309\u5e15\u5229\u54cc\u916e\uff08C23H27FN4O3\uff09\u8ba1\uff0c3.5ml: 700mg\u548c5ml: 1000mg\uff09\uff0c\u6d3b\u6027\u6210\u4efd\u4e3a\u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\uff0c\u7528\u4e8e\u63a5\u53d7\u8fc7\u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\u6ce8\u5c04\u6db2(3M)\u81f3\u5c113\u4e2a\u6708\u5145\u5206\u6cbb\u7597\u7684\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u3002\u5584\u4e45\u8fbe\u00ae\u4ec5\u53ef\u901a\u8fc7\u81c0\u90e8\u808c\u8089\u6ce8\u5c04\u7ed9\u836f\uff0c\u987b\u7531\u4e13\u4e1a\u533b\u62a4\u4eba\u5458\u6ce8\u5c04\u7ed9\u836f\u3002<\/p>\n \u5173\u4e8e<\/strong>\u968f\u673a\u3001\u53cc\u76f2\u3001\u975e\u52a3\u6027\u7684<\/strong>\u5168\u7403\u4e34\u5e8a<\/strong>3<\/strong>\u671f\u7814\u7a76<\/strong>2<\/strong><\/p>\n \u5584\u4e45\u8fbe\u00ae\u7684\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u975e\u52a3\u6548\u6027\u4e34\u5e8a3\u671f\u5168\u7403\u7814\u7a76\u4e2d\uff0c 702\u540d\u5e74\u9f84\u572818\u523070\u5c81\u4e4b\u95f4\u7684\u60a3\u6709\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6210\u5e74\u4eba\u5728\u53cc\u76f2\u671f\u63a5\u53d7\u968f\u673a\u5206\u7ec4\u3002\u7814\u7a76\u65e8\u5728\u8bc1\u660e\u5584\u4e45\u8fbe\u00ae\u5355\u6b21\u7ed9\u836f\u7ec4\u6210\u7684\u6ce8\u5c04\u5468\u671f\u5728\u9884\u9632\u65e2\u5f80\u7a33\u5b9a\u63a5\u53d7\u68d5\u6988\u9178\u5e15\u5229\u54cc\u916e\u6ce8\u5c04\u6db2\u4e00\u4e2a\u6708\u7ed9\u836f\u5236\u5242\uff08\u5584\u601d\u8fbe\u00ae\uff09\u6cbb\u7597\u81f3\u5c114\u4e2a\u6708\u6216\u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\u6ce8\u5c04\u6db2\u4e09\u4e2a\u6708\u7ed9\u836f\u5236\u5242\uff08\u5584\u59a5\u8fbe\u00ae\uff09\u6cbb\u7597\u81f3\u5c111\u4e2a\u6ce8\u5c04\u5468\u671f\uff083\u4e2a\u6708\uff09\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u53d7\u8bd5\u8005\u590d\u53d1\u65b9\u9762\u7684\u6709\u6548\u6027\u4e0d\u4f4e\u4e8e\u5584\u59a5\u8fbe\u00ae2\u6b21\u5e8f\u8d2f\u6ce8\u5c04\u7ed9\u836f\uff0c\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u53cc\u76f2\u671f\u5185\u81f3\u9996\u6b21\u590d\u53d1\u65f6\u95f4\u3002\u6570\u636e\u663e\u793a\uff0c\u57fa\u4e8eKaplan-Meier\u6cd5\u4f30\u8ba1\u503c\u768412\u4e2a\u6708\u53cc\u76f2\u671f\u7ed3\u675f\u65f6\u4ecd\u672a\u590d\u53d1\u7684\u53d7\u8bd5\u8005\u767e\u5206\u6bd4\uff0c\u5584\u4e45\u8fbe\u00ae\u975e\u52a3\u6548\u4e8e\u5584\u59a5\u8fbe\u00ae\u3002<\/p>\n \u5173\u4e8e\u5f3a\u751f<\/strong><\/p>\n \u5728\u5f3a\u751f\uff0c\u6211\u4eec\u575a\u4fe1\u5065\u5eb7\u5c31\u662f\u4e00\u5207\u3002\u51ed\u501f\u6211\u4eec\u5728\u533b\u7597\u5065\u5eb7\u9886\u57df\u7684\u521b\u65b0\u5b9e\u529b\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u6253\u9020\u4e00\u4e2a\u5168\u65b0\u7684\u4e16\u754c\u3002\u5728\u8fd9\u91cc\uff0c\u590d\u6742\u75be\u75c5\u80fd\u591f\u5f97\u5230\u9884\u9632\u3001\u8bca\u7597\u548c\u6cbb\u6108\uff0c\u6cbb\u7597\u65b9\u6cd5\u66f4\u667a\u80fd\u3001\u66f4\u5fae\u521b\u3001\u66f4\u4e2a\u6027\u5316\u3002\u57fa\u4e8e\u6211\u4eec\u5728\u533b\u7597\u79d1\u6280\u548c\u521b\u65b0\u5236\u836f\u4e24\u65b9\u9762\u5f97\u5929\u72ec\u539a\u7684\u7efc\u5408\u5b9e\u529b\uff0c\u6211\u4eec\u5728\u6574\u4e2a\u533b\u7597\u5065\u5eb7\u884c\u4e1a\u4e0d\u65ad\u521b\u65b0\u7a81\u7834\uff0c\u52c7\u6bc5\u524d\u884c\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u4e8b\u4e1a\u7684\u53d1\u5c55\u5e26\u6765\u610f\u4e49\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/p>\n \u66f4\u591a\u4fe1\u606f\u8bf7\u8bbf\u95eehttp:\/\/www.jnj.com\/<\/p>\n [1] \u68d5\u6988\u5e15\u5229\u54cc\u916e\u916f\u6ce8\u5c04\u6db2(6M)\u8bf4\u660e\u4e66, 2024\u5e746\u6708.<\/p>\n [2] \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3. \u5316\u5b66\u836f\u54c1\u76ee\u5f55\u96c6, 2024\u5e745\u670814\u65e5. https:\/\/www.cde.org.cn<\/p>\n [3] Najarian D, et al. A randomized, double-blind, multicenter, noninferiority study comparing Paliperidone Palmitate 6-month versus the 3-month long-acting injectable in patients with schizophrenia. Int J Neuropsychopharmacol. 2022 Mar 17;25(3):238-251.<\/p>\n [4] \u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4. \u7cbe\u795e\u969c\u788d\u8bca\u7597\u89c4\u8303. 2020. P115.<\/p>\n [5] Xiao J, Mi W, Li L, Shi Y, Zhang H. High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People’s Republic of China. Neuropsychiatr Dis Treat. 2015 May 8. 11:1161-7.<\/p>\n [6] Brissos S, Veguilla MR, Taylor D, et al. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Therapeutic Advances in Psychopharmacology. 2014. 4(5):198-219.<\/p>\n [7] Garcia-Portilla MP, et al. Impact on functionality of the paliperidone palmitate three-month formulation in patients with a recent diagnosis of schizophrenia: a real-world observational prespective study. Expert OpinPharmacother. 2022 Jan. 5:1-10.<\/p>\n [8] PungorK, et al. The Patient, Investigator, Nurse, Carer Questionnaire (PINC-Q): a cross-sectional, retrospective, non-interventional study exploring the impact of less frequent medication administration with paliperidone palmitate 3-monthly as maintenance treatment for schizophrenia. BMC Psychiatry 2021 Jun. 21:300.<\/p>\n [9] Najarian D, et al. Long-term efficacy and safety of Paliperidone 6-month formulation: An open-lable 2-year extension of a 1-year double-blind study in adult participants with schizophrenia. 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