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    \n
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      \n
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        \n
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          \n
        1. \u514d\u75ab\u6291\u5236\u4eba\u7fa4\uff1a<\/strong>\u5728\u4e34\u5e8a\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u91cd\u70b9\u5173\u6ce8\u8054\u5408\u7528\u836f\u53ca\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002\u63a8\u8350\u5728\u611f\u67d3\u65e9\u671f\u5408\u7406\u5730\u9009\u7528\u6297\u65b0\u51a0\u75c5\u6bd2\u5c0f\u5206\u5b50\u836f\u7269\uff081A\uff09\u3002\u5bf9\u4e8e\u63a5\u53d7\u73af\u5b62\u7d20\u3001\u4ed6\u514b\u83ab\u53f8\u3001\u897f\u7f57\u83ab\u53f8\u7b49\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u7684<\/strong><\/a>\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u53d7\u8005(SOTR)\u5982\u9700\u670d\u7528\u6765\u745e\u7279\u97e6\uff0c\u4e0d\u5efa\u8bae\u505c\u7528\u514d\u75ab\u6291\u5236\u5242\u3002<\/strong><\/li>\n
        2. \u8001\u5e74\u4eba\u7fa4\uff1a<\/strong>\u6b64\u7c7b\u4eba\u7fa4\u8f83\u5bb9\u6613\u5408\u5e76\u591a\u79cd\u75be\u75c5\uff0c\u5982\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\uff0c\u4f46\u57fa\u7840\u75c5\u7528\u836f\u548c\u6297\u65b0\u51a0\u75c5\u6bd2\u836f\u8054\u5408\u6613\u589e\u52a0 DDI \u98ce\u9669\uff0c\u56e0\u6b64\u300c\u5171\u8bc6\u300d\u5bf9\u6709\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u98ce\u9669\u7684\u8001\u5e74\u60a3\u8005\u63a8\u8350\u5728\u611f\u67d3\u65e9\u671f\u4f7f\u7528\u83ab\u8bfa\u62c9\u97e6\u6216\u5355\u836f 3CLpro \u6291\u5236\u5242\uff08\u6765\u745e\u7279\u97e6\uff09\uff081A\uff09\u3002<\/strong>\u4e14\u6765\u745e\u7279\u97e6\u2162\u671f\u4e34\u5e8a\u7eb3\u5165\u53d7\u8bd5\u8005 0.8% \u5e74\u9f84\u8d85\u8fc7 65\u5c81\uff0c\u7ed3\u679c\u4e5f\u663e\u793a\u4e86\u6765\u745e\u7279\u97e6\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/strong><\/li>\n
        3. \u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/strong>\u7531\u4e8e\u6765\u745e\u7279\u97e6\u4ee5\u539f\u578b\u836f\u7269\u5f62\u5f0f\u7ecf\u7caa\u4fbf\u6392\u6cc4\uff0c\u56e0\u6b64\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/strong>\uff0c\u540c\u65f6\u56e0\u4e0d\u8054\u7528\u5229\u6258\u90a3\u97e6\uff0c\u76f8\u5173\u809d\u635f\u4f24\u98ce\u9669\u8f83\u5c0f\u3002\u300c\u5171\u8bc6\u300d\u6307\u51fa\u5bf9\u4e8e\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u7684\u809d\u3001\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff0c\u5efa\u8bae\u5176\u5728\u611f\u67d3\u65e9\u671f\u4f18\u5148\u9009\u62e9\u83ab\u8bfa\u62c9\u97e6\u548c\u6765\u745e\u7279\u97e6<\/strong>\uff0c\u809d\u529f\u80fd\u4e0d\u5168\u8005\u4f7f\u7528\u6765\u745e\u7279\u97e6\u65f6\u9700\u5bc6\u5207\u76d1\u6d4b\u809d\u529f\u80fd\uff082D\uff09\u3002<\/li>\n<\/ol>\n

          \"\"

          \u300c\u5171\u8bc6\u300d\u5bf9\u6765\u745e\u7279\u97e6\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u7684\u4f7f\u7528\u63a8\u8350[1]<\/p><\/div>\u53ef\u89c1\uff0c\u5355\u836f\u6765\u745e\u7279\u97e6\u4f5c\u4e3a\u65b0\u578b\u76843CLpro\u6291\u5236\u5242\uff0c\u4e3a\u4e34\u5e8a\u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/p>\n

          \u56db\u3001\u6765\u745e\u7279\u97e6\u521b\u65b0\u5355\u836f\u4e3a\u65b0\u51a0\u611f\u67d3\u6cbb\u7597\u5e26\u6765\u66f4\u591a\u7528\u836f\u9009\u62e9<\/strong><\/p>\n

          \u6700\u8fd1\uff0c\u65b0\u51a0\u53d8\u5f02\u682aKP.2\u5728\u5168\u7403\u8303\u56f4\u5185\u5feb\u901f\u4f20\u64ad\uff0c\u4ece\u5168\u7403\u9996\u6b21\u53d1\u73b0KP.2\u5230\u4f20\u81f3\u4e2d\u56fd\uff0c\u4ec5\u75282\u4e2a\u6708[3]<\/sup>\u3002\u9762\u5bf9\u65b0\u51a0\u611f\u67d3\uff0c\u9664\u4e86\u79ef\u6781\u505a\u597d\u9632\u62a4\u63aa\u65bd\uff0c\u9ad8\u5371\u4eba\u7fa4\u611f\u67d3\u540e\u8fd8\u9700\u79ef\u6781\u63a5\u53d7\u6297\u75c5\u6bd2\u6cbb\u7597[2]<\/sup>\u3002\u5c0f\u5206\u5b50\u836f\u7269\u662f\u6297\u51fb\u65b0\u51a0\u7684\u4f18\u5148\u9009\u62e9\uff0c\u800c\u8001\u5e74\u60a3\u8005\u5f80\u5f80\u5408\u5e76\u57fa\u7840\u75be\u75c5\u9700\u540c\u65f6\u670d\u7528\u591a\u79cd\u836f\u7269\uff0c\u4f46\u4e00\u4e9b\u8fdb\u53e3\u836f\u7269\u53ef\u53ca\u6027\u65b9\u9762\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\u3002\u56e0\u6b64\uff0c\u7814\u53d1\u5b89\u5168\u3001\u6709\u6548\u7684\u56fd\u4ea7\u5355\u836f\uff0c\u5e76\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\uff0c\u5bf9\u4e8e\u6cbb\u7597\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u5c24\u4e3a\u91cd\u8981\u3002\u6765\u745e\u7279\u97e6\u7247\u6b63\u662f\u8fd9\u4e00\u80cc\u666f\u4e0b\u5f00\u53d1\u7684\u56fd\u9645\u9996\u6b3e\u65e0\u9700\u8054\u7528\u5229\u6258\u90a3\u97e6\u62df\u80bd\u7c7b3CL\u9776\u5411\u65b0\u51a0\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u662f\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u539f\u521bI\u7c7b\u521b\u65b0\u836f[4]<\/sup>\u3002<\/p>\n

          \u636e\u516c\u5f00\u53d1\u8868\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff1a\u76f8\u5bf9\u4e8e\u5948\u739b\u7279\u97e6\uff0c\u6765\u745e\u7279\u97e6\u4e0e\u9776\u70b9\u76f8\u4e92\u4f5c\u7528\u66f4\u4e3a\u5e7f\u6cdb\uff0c\u5f62\u6210\u7684\u6291\u5236\u590d\u5408\u7269\u66f4\u52a0\u7a33\u5b9a\uff0c\u4f7f\u5f97\u5176\u9776\u70b9\u505c\u7559\u65f6\u95f4\u66f4\u957f<\/strong>\uff0c\u56e0\u6b64\u4e0d\u9700\u8981\u8054\u7528\u5229\u6258\u90a3\u97e6\u4e5f\u80fd\u53d1\u6325\u826f\u597d\u6297\u75c5\u6bd2\u4f5c\u7528[5]<\/sup>\uff1b\u6765\u745e\u7279\u97e6\u5bf9\u8f7b\u81f3\u4e2d\u5ea6\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u6210\u5e74\u60a3\u8005\u6709\u663e\u8457\u7597\u6548\uff0c\u53ef\u4ee5\u663e\u8457\u7f13\u89e3\u4e34\u5e8a\u75c7\u72b6\u3001\u5feb\u901f\u964d\u4f4e\u75c5\u6bd2\u8f7d\u91cf\u3001\u7f29\u77ed\u75c5\u7a0b\u53ca\u8f6c\u9634\u65f6\u95f4<\/strong>[6]<\/sup>\u3002<\/strong><\/p>\n

          \u76ee\u524d\u6765\u745e\u7279\u97e6\u4ece\u57fa\u7840\u673a\u5236\u5230\u4e34\u5e8a\u8bd5\u9a8c\u5b66\u672f\u7814\u7a76\u6210\u679c\u5df2\u7ecf\u9646\u7eed\u53d1\u8868\u4e8e\u56fd\u9645\u9876\u520a\u548c\u56fd\u9645\u6743\u5a01\u671f\u520a\u5b50\u520a\uff0c\u4f53\u73b0\u4e86\u56fd\u9645\u5b66\u672f\u754c\u5bf9\u6765\u745e\u7279\u97e6\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u7684\u8ba4\u53ef\u3002\u540c\u65f6\uff0c\u6765\u745e\u7279\u97e6\u7247\u5df2\u6b63\u5f0f\u7eb3\u51652023\u5e74\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff0c\u53ef\u53ca\u6027\u8fdb\u4e00\u6b65\u63d0\u9ad8[7]<\/sup>\u3002<\/p>\n

          \u603b\u4f53\u800c\u8a00\uff0c\u6765\u745e\u7279\u97e6\u7684\u57fa\u7840\u4e0e\u4e34\u5e8a\u7814\u7a76\u83b7\u5f97\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u56fd\u5bb6\u4e2d\u533b\u836f\u591a\u5b66\u79d1\u521b\u65b0\u56e2\u961f\u9879\u76ee\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u5e7f\u4e1c\u7701\u79d1\u5b66\u6280\u672f\u57fa\u91d1\u3001\u5e7f\u5dde\u5e02\u79d1\u6280\u89c4\u5212\u9879\u76ee\u53ca\u5e7f\u5dde\u5b9e\u9a8c\u5ba4\u653b\u5173\u9879\u76ee\u7684\u8d44\u52a9\u652f\u6301[8]<\/sup>\u3002\u6765\u745e\u7279\u97e6\u7684\u7814\u53d1\u6210\u529f\u662f\u65b0\u578b\u4e3e\u56fd\u4f53\u5236\u4e0b\u6574\u5408\u56fd\u5bb6\u6218\u7565\u79d1\u6280\u529b\u91cf\u8054\u5408\u79d1\u6280\u653b\u5173\u521b\u65b0\u7684\u8303\u4f8b\uff0c\u4e3a\u63a8\u52a8\u56fd\u5185\u65b0\u836f\u7814\u53d1\u7684\u8fdb\u6b65\u53ca\u6211\u56fd\u65b0\u836f\u521b\u65b0\u7814\u53d1\u7684\u7ade\u4e89\u529b\u63d0\u5347\u63d0\u4f9b\u4e86\u4fdd\u969c\u3002<\/p>\n

          \u53c2\u8003\u6587\u732e<\/strong><\/p>\n

          [1] \u4e2d\u534e\u533b\u5b66\u4f1a\u7ec6\u83cc\u611f\u67d3\u4e0e\u8010\u836f\u9632\u6cbb\u5206\u4f1a, \u56fd\u5bb6\u547c\u5438\u533b\u5b66\u4e2d\u5fc3, \u56fd\u5bb6\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3.\u6297\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5c0f\u5206\u5b50\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u4e13\u5bb6\u5171\u8bc6[J].\u4e2d\u534e\u533b\u5b66\u6742\u5fd7,2024,104(20):1812-1824.<\/p>\n

          [2] \u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4,\u56fd\u5bb6\u4e2d\u533b\u836f\u5c40.\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u8bca\u7597\u65b9\u6848(\u8bd5\u884c\u7b2c\u5341\u7248)[J].\u4f20\u67d3\u75c5\u4fe1\u606f, 2023, 36(1):18-25.<\/p>\n

          [3] \u4e2d\u56fd\u75be\u63a7\u4e2d\u5fc3\u5b98\u65b9\u5fae\u535a2024-5-14\u65e5\u62a5\u9053https:\/\/weibo.com\/u\/7289344785<\/p>\n

          [4]\u5e7f\u5dde\u5e02\u4eba\u6c11\u653f\u5e9c\u5b98\u7f51\u62a5\u9053\uff1ahttps:\/\/www.gz.gov.cn\/zt\/yqfkzn\/content\/mpost_8978927.html .<\/p>\n

          [5] Xiaoxin Chen,Xiaodong Huang,Qinhai Ma,et al.Inhibition mechanism and antiviral activity of an \u03b1-ketoamide based SARS-CoV-2 main 2 protease inhibitort. 2023.<\/p>\n

          [6] \u6765\u745e\u7279\u97e6\u8bf4\u660e\u4e66.<\/h1>\n

          [7] \u4f17\u751f\u836f\u4e1a\u5b98\u7f51\uff1a\u559c\u62a5\uff01\u4f17\u751f\u836f\u4e1a1\u7c7b\u521b\u65b0\u836f\u4e50\u777f\u7075\u00ae\u6765\u745e\u7279\u97e6\u7247\u6210\u529f\u7eb3\u51652023\u5e74\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55.http:\/\/www.zspcl.com\/index.php?m=content&c=index&a=show&catid=25&id=673<\/h3>\n

          [8]\u56fd\u5bb6\u547c\u5438\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\u5b98\u65b9\u516c\u4f17\u53f7\u62a5\u9053<\/p>\n

          https:\/\/mp.weixin.qq.com\/s?__biz=MzI2NTEzNDE3Mw==&mid=2650510993&idx=1&sn=fce157f47068d312e58f0303ad87a611&chksm=f2ad3fa3c5dab6b539a585c7a9850de4a1ca5e1048fd50bb0f5ac7f432b5f5ab00f8254e97ed&scene=27<\/p>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

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